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KMID : 0365819740140010273
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Journal of Pusan Medical College
1974 Volume.14 No. 1 p.273 ~ p.282
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Effects of Pulmonary Edema on Surface Activity of Lung
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Abstract
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The effect of pulmonary edema on surface activity of lung extracts was examined in rabbits.
The pulmonary edema was induced by intravenous injection of epinephrine, intravenous infusion of dextran and intratracheal instillation of acid solution, and surface tension properties were measured on saline extracts of lung in order to compare with normal control.
The effect of sodium thiosulfate on these pulmonary edema and surface activity of these lung extracts were also investigated. The results were as follows.
1. The minimum surface tension of excised lung in which pulmonary edema was induced by intravenous injection of epinephrine, intravenous infusion of dextran and intratracheal instillation of acid solution was significantly increased as compared with the normal control of 19.3±3.39 dyne/cm to 27.8±1.61 dyne/cm, 33.8±1. 10 dyne/cm and 33.5±3.70 dyne/cm respectively.
2. The extract stability index of excised lung in pulmonary edema was significantly decreased as compared with the normal control and in proportion to the degree of pulmonary edema.
3. The edematous lung which was induced by intravenous infusion of dextran solution showed a more significant increased minimum surface tension and decreased extract stability index than the other group.
4. The prophylactic administration of sodium thiosulfate lead to a significant increase of pulmonary surface activity of edematous lung. The mechanism of altered surface activity was not explained fully.
5. Author concludes that pulmonary edema leads to an impairment of pulmonary surface activity regardless of the cause of pulmonary edema.
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